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apalutamide will lower the extent or outcome of ketamine by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Steer clear of or Use Alternate Drug. Coadministration of apalutamide, a strong CYP3A4 inducer, with drugs which are CYP3A4 substrates can lead to lower exposure to these prescription drugs.In order to work optimally, our focused cre